eriTrocitebis struqturuli da citoqimiuri Taviseburebani           atopuriBbronquli asTmiTDdaavadebul  bavSvebSi.                          

M med.Mmecn. kand. ninoKkandelaki; med.Mmecn kand.Mmanana sosiaSvili.

Mmarina cxadaia

pediatriis samecniero-kvleviTi instituti.

 

   cnobilia, rom bronquli asTma warmoadgens msoflioSi erT-erT Yyvelaze gavrcelebul daavadebas. mis paTogenezSi mniSvnelovan rols asrulebs eriTrocitTa membranebze lipidTa zeJangvis procesebis darRveva.Bbronquli asTmis mkurnalobis efeqturobis Sesafaseblad, Seswavlil iqna eritrocitTa struqturuli da citoqimiuri monacemebi bronquli asTmis atopuri formiT daavadebuli 80 bavSvis SemTxvevaSi mkurnalobamde da mkurnalobis Semdeg.Aam mizniT Cvens mier gamoyenebul iqna interferenciul-polarizaciuli da maskanirebeli eleqtronuli mikroskopebi.Ggamovlenil iqna eritrocitTa mniSvnelovani struqturuli da citoqimiuri cvlilebebi, rac miuTiTebs organizmis alergiulad Secvlil reaqtiulobaze. Ggamovlenil iqna normocitebis raodenobis sarwmuno daqveiTeba, megalocitebis, naoWiani, “Crdilisebri”eriTrocitebis raodenobis mkveTri mateba, agreTve eriTrocitebis parametrebis cvlilebebi, kerZod sisqis, diametris, ujredis mSrali wonis. maskanirebeli eleqtronuli mikroskopis saSualebiT gamovlenil iqna memrbano-receptoruli sistemis disfunqcia ujredis zedapirze. zaditeniT Catarebuli mkurnalobis Sedegad morfologiuri da citoqimiuri kvlevebiT gamovlenil iqna eriTrocitTa regeneraciuli funqciebis mniSvnelovani gaaqtiveba, sxva mkurnalobis meTodebTan SedarebiT. zaditeni iwvevs membranul receptorTa funqciur rekonstruqcias.

  Cvenma gamokvlevebma cxadyo, rom eriTrocitTa membanebis Seswavla maskanirebeli mikroskopis saSualebiT, aris metad informatiuli daavadebis simZimis da Catarebuli mkurnalobis efeqturobis Sesafaseblad.                                                               

                                             

        STRUCTURAL AND CYTOCHEMICAL PECULIARITIES OF ERYTHROCYTIES

                  I N CHILDREN WITH ATOPIC BRONCHIAL ASTHMA.

Nino Kandelaki M.D. Manana Sosiashvili M.D. Marina Tskhadaia

Scientific-research Institute of Pediatrics. Tbilisi.  GEORGIA.

   It is known that bronchial asthma is the chronic inflammatory disease and that among other peripheral blood cells, erythrocytes have great importance to be investigated to understand the pathogenesis of this process.

   To estimate the efficacy of treatment before and after ZADITEN administration on the basis of structural and cytochemical data total 80 patients with atopic asthma were examined. Children with atopic asthma were divided into two age groups. We made morphological and cytochemical studies of peripheral blood erythrocytes in acute period of illness-before and after treatment. Our material we investigated with the use of method of direct erythro-cytometry and with the aid scanning electron microscopy. In the material the erythrocytes are presented differently before and after treatment. It includes: cell thickness, dry weight unity on surface, and concentration of dry substance unity on surface. The therapy with sympatomimetics, bronchospasmolitics, hormones do not restore the whole structural and cytochemical changes of erythrocytes. Therefore, we observed after ZADITEN administration in both groups significant restoration of erythrocyte membranes. According to this data, we can judge about the efficiency of the treatment, the severity of disease and the ability of the prognoses of the disease.

Aavtoris el-fosta NNnkandelaki@hotmail.com  390009  Tbilisi meliqiSvilis 5

  tel (+995)(32)  252418 Mmob (+995)  (93) 352419 nino Kkandelaki.