bioorganuli qimia da garemosTan adamianis adaptacia

 

ramaz gaxokiZe

 

Tbilisis saxelmwifo universitetis bioorganuli qimiis kaTedris gamge, profesori

 

bioorganuli qimia urTulesi biologiuri sistemebis kvlevis saSua­lebas iZleva. SesaZlebeli gaxda insulinisa da asobiT mniSvnelovani ci­lis struqturis dadgena, mravali biologiurad aqtiuri peptidis, bio­re­gu­latoris (prostaglandinebi, tetraciklinebi, qlorofili, B12-vi­ta­mi­ni), ci­lis da genis sinTezi. bioorganuli qimiis am miRwevebma gansazRvres bio­lo­giisa da medicinis Semdgomi ganviTareba, rasac Rrma zogad­filo­so­fiu­ri mniSvneloba aqvT.

garemosTan adamianis adaptacia ori gziTaa SesaZlebeli. pirveli _ garemos dacvis gaumjobesebiT, meore _ TviT adamianis organizmis mdgra­do­bis gazrdiT sayofacxovrebo mavne faqtorebis moqmedebis mimarT.

gansakuTrebiT yuradRebas ipyrobs iseTi nivTierebebi, romlebic iwve­ven Cveulebriv pirobebSi aumoqmedebel sarezervo meqanizmebis mobilizebas da zrdian organizmis mdgradobas. moqmedebis meqanizmis mixedviT aseTi nivTie­re­bebi SeiZleba davyoT stimulatorebad, adaptogenebad da bio­en­ergo­aqti­vatorebad.

stimulatorebi (kerZod, dopingebi) aCqareben energiis gamoyofas orga­nizmSi, rac iwvevs nervuli sisitemis daZabvas da sabolood gamofitvas. adaptogenebis gamoyenebisas ki adgili aqvs organizmis dacviTi Zalebis harmoniul mobilizebas, radgan aseTi nivTierebebi uSualod moqmedeben qsovilur metabolizmze, aZliereben gonebriv da fizikur Sromisuna­ria­no­bas da organizms emociuri stresebisa da sxva eqstremuli zemoqme­de­bi­sagan icaven. mniSvnelovani mcenareuli adaptogenebia: JenSenis, eleute­ro­kokis, Cinuri limonuras, manjuriuli araliis, eqinopanaqsis, rodiolas, lezviasa da sxva mcenareebisagan miRebuli preparatebi. magaliTad, 30 dRis ganmav­lobaSi eleuterokokis miReba orjer amcirebs gripiT daavadebas.

savaraudoa adaptogenebis organizmze moqm­e­de­bis ori hipoTeza. pirve­lis mixedviT, adaptogenebi warmoadgenen sust gamRizianeblebs (streso­rebs), e.i. organizms mcired azianeben da amiT xels uwyoben dacviTi Zalebis mo­bilizacias. sxva SesaZleblobaa _ adap­togenebis rezistinebis (orga­nizmSi warmoqmnil damcvel nivTierebaTa) ana­lo­giurad funqcio­nireba. es SeiZleba infeqciur daavadebaTa aqtiur da pasiur imunoTerapias SevadaroT. aqtiuri imunoTerapiisas organizmSi SeyavT infeqciuri agentis sawinaaRmdego antisxeulis warmomqneli niv­Tie­reba. pasiuri imunoTerapiis SemTxvevaSi iyeneben mza antisxeulebs, rom­lebic uSualod aneitraleben infeqcias.

adaptogenebis mravalmxrivi moqmedeba ujredul sistemebze iwvevs me­ta­bo­lizmis keTilmyofel cvlilebas sxvadasxva mimarTulebiT. adapto­genebma SeiZleba imoqmedos centralur-nervul an endokrinul sisitemaze, agreTve UuSualod Secvalos ujredul receptorTa mgrZnobiaroba neirome­dia­torebisa da hormonebis moqmedebis mimarT. erTi tipis receptorebi dakavSirebulia membranaSi lokalizebul ferment adenilatciklazasTan, romelic adenoziltrifosformJavas (atf) gardaqmnis ciklur adenozin­monofosformJavad (c-amf). es ukanaskneli iwvevs A-proteinkinazis gaaq­tiurebas, romelic, Tavis mxriv, axdens naxSirwylovani da cximovani cvlis fermentul sisitemaTa stimulirebas, ris Sedegadac adgili aqvs energiiT mdidar (makroergul) nivTierebaTa dagrovebasa da energetikuli cvlis intensifikacias. meore tipis receptorebi urTierTqmedeben membranasTan bmul sxva fermentTan _ C-fosfolipazasTan, romelic fosfoti­dili­nozi­tol­fos­fatTan warmoqmnis diacilglicerols, romelic C-proteiki­na­zis aqtivators warmoadgens. es fermenti axdens cilis biosinTezis sistemis stimulirebas da ucxo nivTierebaTa gamauvnebel fermentTa sinTezis inducirebas. amasTan erTad, adaptogens SeuZlia membranaze uSualod zemoqmedeba, maTi struq­turuli mdgomareobis da, Sesabamisad, seleqtiuri ganvladobis Secvla, adaptogens SeuZlia Sebrunebuli Jangva-aRdgena da axasiaTebs antioqsi­dan­turi Tvisebebi (aferxebs ujredis JangviT daSlas).

adaptogenebiT gamowveul metabolitur gardaqmnaTa moqmedebiT xdeba organizmis dacviTi rezervebis mobilizeba, iwyeba RviZlsa da kunTebSi glikogenis dagroveba, kunTis qsovilis zrda, kunTebis SekumSvis Zalis momateba SemkumSveli cilebisa da makroergul nivTierebaTa gadidebis xarjze. adgili aqvs imunuri sistemis aqtivaciasac. adaptogenebis moqme­debiT stabilizirdeba histohematuri barierebi (ujredTa kapilarebis membra­nebis sistema, romelic akontrolebs sisxlsa da qsovilebs Soris nivTierebaTa gadatanas). es imasTanaa dakavSirebuli, rom adaptogenebi xels uSlian ze­Jangebis dagrovebas, romlebic membranebs azianeben. toq­sikur nivTiere­bebisadmi mdgradobis gazrda ganpirobebulia adaptogenebiT citoqrom R-450-is _ ucxo naerTTa damSleli sistemis ZiriTadi fermentis biosinTezis sti­mulaciiT. saboloo jamSi adaptogenebis sxvadasxva doneze gardaqmnebi iwveven araspecifiuri imunitetis gazrdas.

meore gzaa damcveli Zalebis mobilizacia _ adaptogenebis organizmis antiJangviTi sistemis aqtivacia. gansakuTrebiT mniSvnelovania organizmis imunur dacvaSi monawile bioregulatorebis (interferonis, interleiki­nis) sinTezis stimulireba. am dros izrdeba infeqciebisadmi mdgradoba. garda amisa, adaptogenebi aCqareben ujredis struqturuli cilebis sinTezs. swo­red amiT aixsneba kunTis qsovilis gazrdisa da kunTis Zalis gaZlie­rebis unari. amgvarad, saboloo jamSi, izrdeba organizmis mdgra­doba sxvadasxva eqtremuli moqmedebis mimarT.

adaptogenur saSualebaTa arsenali jer kidev Zalian mcirea. mis gasafarToveblad empiriul ZiebasTan erTad friad mniSvnelovania bunebriv adaptogenTa analogebis an kompleqsur preparatTa mizanmimarTuli Seqmna, romelTa komponentebi sasikeTod moqmedebs qsoviluri metabolizmis rgo­lebze. Cven mier bunebriv naerTTa transformaciis Sedegad miRebulia nivTierebebi, romelTac bioenergoaqtivatorebi vuwodeT. maT safuZvelze Seq­mnilia preparatebi "vitaragi", "rameri", romelTac axasiaTebT maRali anti­mutagenuri aqtivoba. isini monawileoben nivTierebaTa cvlaSi, ionTa tran­sportSi, glukozis utilizaciasa da sxva procesebSi. aZliereben medegobas mZime liTonebis, fosfororganuli nivTierebebis da radiaciis moqmedebis mimarT. bioener­go­aqti­vatorebis moqmedebis Seswavlam gviCvena, rom isini stre­sul pirobebSi ujreds amarageben limonmJaviTa da sunTqvi­saTvis sxva aucile­beli komponentebiT da zrdian bioenergopo­tencials. preparati "ra­meri" mniSvne­lov­nad amaRlebs gonebriv da fizikur Sromisunarianobas, aseve garemos uaryofiTi zemoqmmdebisadmi organizmis winaaRmdegobis unars.

ekologiuri stresebis gasauvneblad saWirod migvaCnia adaptogenebisa da bioenergoaqtivatorebis farTod gamoyeneba yoveldRiur cxovrebaSi. sasur­ve­lia maTi damateba ualkoholo sasmelebSi, sakonditro nawarmSi (marmeladi, draJe, kanfetebi) da saReW rezinSic ki.

Bioorganic Chemistry and Adaption of Human with Environmental

 

Ramaz Gakhokidze

 

Head of Department of Bioorganic chemistry of

Tbilisi State University, Chavchavadze ave, 1, Tbilisi, 380079, Georgia

 

 

There are two ways of adaptation of human with environmental. The first - improvement of environmental preservation, the second - increase the stability of organisms towards the action of harmfull factors on the basis of the methods of bioorganic chemistry.

Adaptation of organisms to the different conditions is possible through the usage of bio-energo-activators, which were obtained in our laboratory.

Bio-energo-activator enables preservation of homeostasis through activation of physiological regulatory mechanisms, providing adaptation to the extremal conditions.

In our laboratory on the basis of bio-energo-activators many highly-effective medical preparations have been created. Namely an ,,Vitarag'' ointment, which contains ecologcially pure biological products, is used in cases of inflamatory, parulent and fungal diseases, for trating furunculus, burns, arthritis, myositis, mastitis, red wind, diseases of mucosal layer of nasal and oral cavities, piles, erosion and ulcar of uterine cervix. It accelerates healing of wounds, it stops alopecia, skin aging, destroys wrinkles and swelling of periorbital areas.

A unique drug "Ramer" has been created for regulating homeostatic curing neurosis, hy­per­ten­sion, increases mental, physical and sexual potention, has general rehabilitation effect, it strengthens the organism's resistance against diseases and external factors.

 

 

 

Tel.:  (995 32) 22 50 30;  (995 32) 25 15 53   

FAX : (995 32) 25 1876

E-mail : rgakhokidze @hotmail. com